Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.45 |
| ▸ | TYK2 | P29597 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 7/20 | 0.34 |
| ▸ | DRD3 | P35462 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9920321 | 1.00 | JAK1 (0.45) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL9898496 | 0.84 | JAK1 (0.47) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL9923315 | 0.84 | JAK1 (0.47) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL9923340 | 0.84 | JAK3 (0.45) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL9920438 | 0.82 | JAK2 (0.46) | JAK1TYK2JAK3JAK2 | |
| SCHEMBL9920437 | 0.80 | JAK2 (0.50) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL9920435 | 0.79 | ACHE (0.36) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL12395231 | 0.78 | JAK3 (0.60) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL12395222 | 0.73 | JAK3 (0.54) | JAK1TYK2JAK3JAK2ACHE | |
| SCHEMBL12395224 | 0.73 | JAK3 (0.52) | JAK1TYK2JAK3JAK2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | JAK1 1/4885TYK2 10/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.