Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 6/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | USP10 | Q14694 | 1/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | USP13 | Q92995 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13171087 | 0.89 | HTT (0.39) | HTTHDAC1HDAC8HDAC6MAPT | |
| SCHEMBL9921329 | 0.87 | HTT (0.38) | HTTAURKAAURKBMAPTPOLB | |
| SCHEMBL9921375 | 0.83 | HTT (0.65) | HTTAURKAAURKBRPS6KB1USP10 | |
| SCHEMBL9921326 | 0.82 | HTT (0.44) | HTTAURKAMEN1KMT2AMAPT | |
| SCHEMBL13171094 | 0.80 | GALR3 (0.38) | HTTMEN1KMT2AMAPTPOLB | |
| SCHEMBL22714182 | 0.80 | HTT (0.40) | HTTUSP10PIK3C3USP13MEN1 | |
| SCHEMBL9921323 | 0.78 | HTT (0.52) | HTTMEN1KMT2AMAPTPOLB | |
| SCHEMBL9921335 | 0.78 | HTT (0.60) | HTTMEN1KMT2AMAPTSLC29A1 | |
| SCHEMBL9921325 | 0.78 | HTT (0.55) | HTTUSP10PIK3C3USP13MEN1 | |
| SCHEMBL9921415 | 0.77 | MAPT (0.59) | HTTAURKARPS6KB1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |