Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.60 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.55 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9921330 | 0.88 | HTT (0.47) | HTTTTBK1TTBK2LMNAMEN1 | |
| SCHEMBL9921325 | 0.88 | HTT (0.55) | HTTTTBK1TTBK2LMNAMEN1 | |
| SCHEMBL9921323 | 0.88 | HTT (0.52) | HTTTTBK1TTBK2LMNAMEN1 | |
| SCHEMBL9921422 | 0.85 | HTT (0.50) | HTTTTBK1TTBK2LMNATSHR | |
| SCHEMBL13171084 | 0.85 | HTT (0.45) | HTTTTBK1TTBK2LMNAMEN1 | |
| SCHEMBL9921415 | 0.84 | MAPT (0.59) | HTTLMNAMEN1TSHRKMT2A | |
| SCHEMBL9921326 | 0.84 | HTT (0.44) | HTTTTBK1TTBK2LMNAMEN1 | |
| SCHEMBL9921423 | 0.82 | HTT (0.47) | HTTLMNAMEN1TSHRKMT2A | |
| SCHEMBL9921352 | 0.81 | HTT (0.81) | HTTTTBK1TTBK2LMNANR2F2 | |
| SCHEMBL13171100 | 0.80 | HTT (0.56) | HTTTTBK1TTBK2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |