Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 8/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.42 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13171084 | 0.90 | HTT (0.45) | HTTNR2F2TTBK1TTBK2LMNA | |
| SCHEMBL9921335 | 0.88 | HTT (0.60) | HTTNR2F2TTBK1TTBK2LMNA | |
| SCHEMBL9921325 | 0.83 | HTT (0.55) | HTTNR2F2TTBK1TTBK2LMNA | |
| SCHEMBL9921323 | 0.83 | HTT (0.52) | HTTNR2F2TTBK1TTBK2LMNA | |
| SCHEMBL9921422 | 0.81 | HTT (0.50) | HTTNR2F2TTBK1TTBK2LMNA | |
| SCHEMBL9921326 | 0.80 | HTT (0.44) | HTTNR2F2TTBK1TTBK2LMNA | |
| SCHEMBL9921415 | 0.80 | MAPT (0.59) | HTTNR2F2LMNATSHRPOLB | |
| SCHEMBL9921336 | 0.79 | HTT (0.46) | HTTNR2F2LMNATSHRPOLB | |
| SCHEMBL13171094 | 0.78 | GALR3 (0.38) | HTTLMNATSHRPOLBMAPT | |
| SCHEMBL9921423 | 0.78 | HTT (0.47) | HTTNR2F2LMNATSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |