Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1079194 | 0.81 | HTR7 (0.39) | HTR7HTR6SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL1079190 | 0.81 | HTR7 (0.39) | HTR7HTR6SMN1; SMN2ALDH1A1HSD11B1 | |
| SCHEMBL991769 | 0.80 | HTR7 (0.39) | SLC6A2SLC6A3SLC6A4HTR7HTR6 | |
| SCHEMBL11539874 | 0.71 | TSHR (0.44) | SLC6A2SLC6A3SLC6A4HTR7HTR6 | |
| SCHEMBL11538270 | 0.70 | TSHR (0.47) | SLC6A2SLC6A3SLC6A4HTR7HTR6 | |
| SCHEMBL20041877 | 0.69 | SLC6A4 (0.45) | SLC6A2SLC6A3SLC6A4HTR6CYP2D6 | |
| SCHEMBL1060453 | 0.68 | SLC6A4 (0.46) | SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL1060452 | 0.68 | SLC6A4 (0.46) | SLC6A2SLC6A3SLC6A4CYP2D6 | |
| SCHEMBL1079151 | 0.68 | HTR7 (0.54) | SLC6A2SLC6A3SLC6A4HTR7HTR6 | |
| SCHEMBL1079153 | 0.68 | HTR7 (0.54) | SLC6A2SLC6A3SLC6A4HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454234-A2 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | Theravance, Inc. (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008666-A2 | 3-PHENOXYMETHYLPYRROLIDINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-01-20 | — | — | WO | disclosed |