Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353556 | 0.86 | BCHE (0.50) | DNM1OPRD1OPRK1MEN1ALDH1A1 | |
| SCHEMBL421960 | 0.86 | EPHX1 (0.61) | OPRD1OPRK1EPHX1MEN1KMT2A | |
| SCHEMBL421959 | 0.86 | EPHX1 (0.61) | OPRD1OPRK1EPHX1MEN1KMT2A | |
| SCHEMBL11121889 | 0.84 | EPHX1 (0.59) | OPRD1OPRK1EPHX1MEN1KMT2A | |
| SCHEMBL28387015 | 0.81 | MEN1 (0.54) | DNM1MEN1ALDH1A1GAAMAPT | |
| SCHEMBL23529711 | 0.78 | MMP2 (0.57) | OPRD1OPRK1EPHX1SMN1; SMN2ANPEP | |
| SCHEMBL23529709 | 0.78 | MMP2 (0.57) | OPRD1OPRK1EPHX1SMN1; SMN2ANPEP | |
| SCHEMBL4614132 | 0.77 | EPHX1 (0.50) | EPHX1ANPEPPPARGPPARAMAOB | |
| SCHEMBL13405115 | 0.76 | EPHX1 (0.53) | EPHX1ANPEPMMP2MAOABACE1 | |
| SCHEMBL17710346 | 0.76 | MEN1 (0.59) | OPRD1OPRK1EPHX1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981884-B1 | THIAZOLE COMPOUNDS AS PROTEIN KINASE B (PKB) INHIBITORS | AMGEN INC (US) | 2012-06-13 | — | — | EP | disclosed |