Sugi Predict

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SCHEMBL9922992

SCHEMBL9922992

CNc1ccc2c(=O)n(-c3c(F)cc(NC(=O)NS(=O)(=O)c4ccc(Cl)s4)cc3C(F)(F)F)ccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RY12 Q9H244 1/20 0.47
▸ TRPV1 Q8NER1 2/20 0.35
▸ FBP1 P09467 2/20 0.34
▸ MAPT P10636 2/20 0.33
▸ PTPN2 P17706 4/20 0.33
▸ PTPN1 P18031 4/20 0.33
▸ PTPN5 P54829 4/20 0.33
▸ PPARG P37231 1/20 0.32
▸ RAF1 P04049 1/20 0.32
▸ MAPK3 P27361 1/20 0.32
▸ APP P05067 1/20 0.31
▸ MEN1 O00255 2/20 0.31
▸ KMT2A Q03164 2/20 0.31
▸ CA9 Q16790 3/20 0.31
▸ KDR P35968 1/20 0.31
▸ CA1 P00915 2/20 0.30
▸ CA2 P00918 2/20 0.30
▸ CA7 P43166 2/20 0.30
▸ HSPD1 P10809 2/20 0.30
▸ HSPE1 P61604 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9922990 0.93 P2RY12 (0.51) P2RY12FBP1MAPTMEN1KMT2A
SCHEMBL12161667 0.91 P2RY12 (0.49) P2RY12FBP1MAPTMEN1KMT2A
SCHEMBL9922995 0.89 P2RY12 (0.48) P2RY12FBP1MAPTMEN1KMT2A
SCHEMBL9922985 0.88 P2RY12 (0.47) P2RY12TRPV1FBP1MAPTPPARG
SCHEMBL13633801 0.88 P2RY12 (0.47) P2RY12FBP1MAPTMEN1KMT2A
SCHEMBL14228344 0.88 P2RY12 (0.47) P2RY12FBP1MAPTMEN1KMT2A
SCHEMBL9923006 0.87 P2RY12 (0.46) P2RY12TRPV1FBP1MAPTPTPN2
SCHEMBL9922112 0.86 P2RY12 (0.53) P2RY12FBP1MAPTMEN1KMT2A
SCHEMBL13638632 0.85 P2RY12 (0.42) P2RY12MEN1KMT2ACA9CA1
SCHEMBL9922997 0.83 P2RY12 (0.48) P2RY12FBP1MAPTMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8524721-B2 Platelet ADP receptor inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2013-09-03 — — US disclosed
US-20120149688-A1 PLATELET ADP RECEPTOR INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2012-06-14 — — US disclosed
US-8067428-B2 Platelet ADP receptor inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2011-11-29 — — US disclosed
US-8067428-B2 Platelet ADP receptor inhibitors PORTOLA PHARMACEUTICALS, INC. (US) 2011-11-29 — — US disclosed
US-20100234350-A1 PLATELET ADP RECEPTOR INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2010-09-16 — — US disclosed
US-20100234350-A1 PLATELET ADP RECEPTOR INHIBITORS PORTOLA PHARMACEUTICALS, INC. (US) 2010-09-16 — — US disclosed
US-7358257-B2 sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents PORTOLA PHARMACEUTICALS, INC. (US) 2008-04-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100234350-A1 PLATELET ADP RECEPTOR INHIBITORS TBXA2R, GP6, P2RY6 P2RY12 19/4885TRPV1 577/4885FBP1 1584/4885
US-20120149688-A1 PLATELET ADP RECEPTOR INHIBITORS TBXA2R, GP6, P2RY6 P2RY12 18/4885TRPV1 565/4885FBP1 1579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.