GP6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL274470	0.49	3/20
SCHEMBL274645	0.44	3/20
SCHEMBL274352	0.40	3/20
SCHEMBL274853	0.40	3/20
SCHEMBL273368	0.39	3/20
SCHEMBL274077	0.38	3/20
SCHEMBL1249268	0.63	2/20
SCHEMBL613321	0.62	2/20
SCHEMBL1249266	0.61	2/20
SCHEMBL400222	0.61	2/20
SCHEMBL1250616	0.60	2/20
SCHEMBL1248713	0.60	2/20
SCHEMBL1250333	0.54	2/20
SCHEMBL1351636	0.52	2/20
SCHEMBL1351781	0.52	2/20
SCHEMBL1249292	0.51	2/20
SCHEMBL1250105	0.51	2/20
SCHEMBL1250934	0.51	2/20
SCHEMBL1055134	0.51	2/20
SCHEMBL1249156	0.51	2/20

Clinical trials — most relevant to GP6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
COMT on Aspirin Platelets Effects (CAPE)	PHASE4	UNKNOWN
The Effect of IV Cangrelor and Oral Ticagrelor Study	PHASE4	COMPLETED
Antiplatlet Effects of Standardized Tomato Extract in Hypertensive Subjects	PHASE4	COMPLETED
Nebulized Heparin in Severe Acute Respiratory Syndrome COVID-19	PHASE4	UNKNOWN
Association of FcγRIIIA Polymorphism and THPO Expression With Response to Eltrombopag in Refractory ITP Patients	PHASE3	UNKNOWN
Cangrelor on Top of anticoagUlation in Patients With myocaRdial Infarction-related Cardiogenic Shock/Cardiac Arrest receiVIng VA-ECMO	PHASE2	RECRUITING
Intracoronary Stenting and Antithrombotic Regimen: Lesion Platelet Adhesion as Selective Target of Endovenous Revacept	PHASE2	COMPLETED
Safety and Efficacy of Zanubrutinib in the Treatment of Antiphospholipid Syndrome With Secondary Thrombocytopenia	PHASE2	RECRUITING
Use of Vitamin D as An Adjuvant Treatment in Children With Chronic Idiopathic Thrombocytopenic Purpura	EARLY_PHASE1	UNKNOWN
In-vivo Thrombus Imaging With 18F-GP1, a Novel Platelet PET Radiotracer	nan	COMPLETED
The MyoThrombus Study	nan	COMPLETED
The Effect of Eltrombopag on the Expression of Platelet Collagen Receptor GPVI in Pediatric ITP.	nan	COMPLETED
Anti-αIIbβ3 Immunization in Glanzmann Thrombasthenia: Prevalence and Associated Risk Factors: Thrombasthenia Anti-αIIbβ3 Antibodies Study (TAAS)	nan	COMPLETED
Clinical Pattern of Glanzemnn Thrombathenia in Children Attending Assiut University Children Hospital	nan	NOT_YET_RECRUITING
The Effect of Pulsed-field and Radiofrequency Ablation on Platelet, Coagulation and Inflammation	nan	UNKNOWN
Aetiology And Outcome Of Children With Thrombocytosis Admitted to Assiut University Children Hospital	nan	UNKNOWN
Risk Factors of Thrombocytopenia In Chronic Kidney Disease And Hemodialysis Patients In Assiut University Hospitals	nan	UNKNOWN
The Effect of Vitamin D Supplementation on HIV-associated Platelet Hyperreactivity	nan	COMPLETED
Primary Hemostasis Pathology in Patients on ECMO During Lung Transplantation	nan	COMPLETED
Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children	nan	NOT_YET_RECRUITING
Hormone Replacement Therapy and Prothrombotic Variants	nan	COMPLETED
Platelets Function and Cardiovascular Events in Patients With End Stage Renal Disease	nan	UNKNOWN
Short-Term Application of Tocilizumab Following Myocardial Infarction	nan	COMPLETED
Study of Constitutional Platelet Disease	nan	UNKNOWN
Identification of Donors of CD36-Deficient Platelets Among Japanese Individuals on the NIH Campus	nan	COMPLETED
A Study to Identify Biomarkers of Hypoglycaemia in Patients With Type 2 Diabetes	nan	COMPLETED
Transmission Electron Microscopy Images for Platelet Ultrastructural Criteria Before and After the Onset of an Antiplatelet Agent	nan	RECRUITING
The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications	nan	COMPLETED
COVID-19 Coagulopathy Extension Study	nan	RECRUITING
Omega-3 Fatty Acids Supplementation and Atherothrombotic Biomarkers in Type 2 Diabetes and Cardiovascular Disease.	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GP6 binder may also engage these)

Protein	Name	Similarity
P0C191	—	0.985	P0C191 →
Q863H2	—	0.983	Q863H2 →
O75019	—	0.979	O75019 →
O76036	—	0.978	O76036 →
Q95JB9	—	0.978	Q95JB9 →
Q8N6C8	—	0.977	Q8N6C8 →
Q8N149	—	0.976	Q8N149 →
Q8MJZ2	—	0.976	Q8MJZ2 →
O75022	—	0.973	O75022 →
A6NI73	—	0.972	A6NI73 →
Q6PI73	—	0.969	Q6PI73 →
Q8N423	—	0.969	Q8N423 →
Q9Z0H5	—	0.968	Q9Z0H5 →
Q6ISS4	—	0.966	Q6ISS4 →
P59901	—	0.966	P59901 →
Q6GTX8	—	0.965	Q6GTX8 →
O75023	—	0.964	O75023 →
Q8C567	—	0.963	Q8C567 →
Q8IYS5	—	0.962	Q8IYS5 →
Q8MJZ7	—	0.962	Q8MJZ7 →
A0A0K2S4Q6	—	0.958	A0A0K2S4Q6 →
Q8VBT3	—	0.957	Q8VBT3 →
Q8NHL6	—	0.955	Q8NHL6 →
Q08708	—	0.955	Q08708 →
Q28110	—	0.954	Q28110 →
Q96LA6	—	0.952	Q96LA6 →
Q496F6	—	0.952	Q496F6 →
Q8NHJ6	—	0.947	Q8NHJ6 →
Q96LA5	—	0.946	Q96LA5 →
A8MVS5	—	0.945	A8MVS5 →