Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923397 | 0.84 | MAP2K1 (0.39) | MAP2K1 | |
| SCHEMBL9923284 | 0.79 | JAK1 (0.51) | — | |
| SCHEMBL1160473 | 0.79 | MAP2K1 (0.44) | MAP2K1 | |
| SCHEMBL9923090 | 0.76 | JAK1 (0.43) | CSNK2A1 | |
| SCHEMBL1160527 | 0.76 | MAP2K1 (0.53) | MAP2K1CSNK2A1 | |
| SCHEMBL9923337 | 0.75 | CSNK2A1 (0.46) | MAP2K1CSNK2A1 | |
| SCHEMBL9923309 | 0.75 | CDK2 (0.33) | — | |
| SCHEMBL9923311 | 0.75 | PIK3CA (0.35) | MAP2K1 | |
| SCHEMBL9923313 | 0.75 | KDM4E (0.33) | — | |
| SCHEMBL9923304 | 0.72 | JAK1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | MAP2K1 548/4885CSNK2A1 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.