Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923089 | 0.84 | MAP2K1 (0.46) | MAP2K1 | |
| SCHEMBL9923398 | 0.81 | JAK3 (0.47) | LMNAHTT | |
| SCHEMBL12875307 | 0.81 | MAPT (0.40) | MAP2K1LMNAHTT | |
| SCHEMBL9923311 | 0.79 | PIK3CA (0.35) | MAP2K1LMNA | |
| SCHEMBL9923076 | 0.77 | CSNK2A1 (0.36) | MAP2K1LMNA | |
| SCHEMBL9923090 | 0.73 | JAK1 (0.43) | — | |
| SCHEMBL9923309 | 0.72 | CDK2 (0.33) | EPHB3 | |
| SCHEMBL9923313 | 0.72 | KDM4E (0.33) | — | |
| SCHEMBL9923304 | 0.71 | JAK1 (0.36) | HTT | |
| SCHEMBL9923264 | 0.71 | JAK1 (0.36) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | BIOCRYST PHARMACEUTICALS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149691-A1 | Pyrrolo [1,2-b] Pyridazine Derivatives as Janus Kinase Inhibitors | JAK1, JAK2, JAK3 | MAP2K1 548/4885LMNA 4792/4885HTT 4733/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.