Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 3/20 | 0.57 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.37 |
| ▸ | CDK8 | P49336 | 3/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23114402 | 0.84 | PRKCI (0.59) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL1951102 | 0.79 | NUDT1 (0.44) | PRKCIAXLNUDT1JAK2JAK1 | |
| SCHEMBL17681732 | 0.79 | PRKCI (0.49) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL22380076 | 0.79 | PRKCI (0.41) | PRKCIAXLNUDT1CITJAK2 | |
| SCHEMBL23022192 | 0.79 | JAK1 (0.46) | PRKCIAXLNUDT1JAK2JAK1 | |
| SCHEMBL8324165 | 0.76 | PRKCI (0.67) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL15155103 | 0.73 | PRKCI (0.62) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL23089249 | 0.73 | PRKCI (0.62) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL12593919 | 0.73 | PRKCI (0.62) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL12561934 | 0.73 | PRKCI (1.00) | PRKCIAXLCCNKCDK12NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |