Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.87 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645047 | 0.93 | GCK (1.00) | GCKNPC1RAB9AKCNH2MITF | |
| SCHEMBL643901 | 0.83 | GCK (0.66) | GCKNPC1RAB9AKCNH2L3MBTL1 | |
| SCHEMBL645334 | 0.82 | GCK (0.78) | GCKNPC1RAB9AKCNH2MITF | |
| SCHEMBL646447 | 0.81 | GCK (0.75) | GCKNPC1RAB9AKCNH2MITF | |
| SCHEMBL643669 | 0.81 | GCK (0.84) | GCKKCNH2 | |
| SCHEMBL646229 | 0.79 | GCK (0.74) | GCKNPC1RAB9AKCNH2MITF | |
| SCHEMBL644431 | 0.79 | GCK (0.71) | GCKNPC1RAB9AKCNH2MITF | |
| SCHEMBL15780547 | 0.76 | GCK (0.58) | GCKNPC1RAB9AKCNH2L3MBTL1 | |
| SCHEMBL2644922 | 0.76 | GCK (0.72) | GCKNPC1GAACNR1 | |
| SCHEMBL643010 | 0.75 | L3MBTL1 (0.57) | GCKNPC1RAB9AKCNH2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |