Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10253338 | 0.91 | PTGS2 (0.48) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL646057 | 0.86 | PTGS2 (0.39) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL645021 | 0.86 | GCK (0.49) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL12101428 | 0.84 | HPGD (0.39) | PTGS2HPGDICAM1SELEKDM4E | |
| SCHEMBL2663647 | 0.84 | PTGS2 (0.37) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL10253218 | 0.80 | PTGS2 (0.47) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL12101423 | 0.76 | SLC6A4 (0.42) | PTGS2HPGDICAM1SELEALDH1A1 | |
| SCHEMBL643757 | 0.76 | GCK (0.47) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL642524 | 0.76 | GCK (0.41) | PTGS2HPGDAKR1B1ICAM1SELE | |
| SCHEMBL10257477 | 0.76 | PTGS2 (0.48) | PTGS2HPGDICAM1SELEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463283-A1 | Fused phenyl Amido heterocyclic compounds for the prevention and treatment of glucokinase-mediated diseases | Pfizer Products Inc. (US) | 2012-06-13 | — | — | EP | disclosed |