Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.40 |
| ▸ | JAK3 | P52333 | 9/20 | 0.38 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923093 | 0.86 | CAMKK2 (0.38) | AXLJAK3JAK2 | |
| SCHEMBL9923305 | 0.78 | AXL (0.43) | AXLMAP2K1NR4A2JAK3JAK2 | |
| SCHEMBL9923353 | 0.75 | CHEK1 (0.40) | — | |
| SCHEMBL31403744 | 0.74 | AXL (0.44) | AXLMAP2K1NR4A2JAK3JAK2 | |
| SCHEMBL29953241 | 0.73 | MAP2K1 (0.54) | AXLMAP2K1NR4A2JAK3JAK2 | |
| SCHEMBL29951791 | 0.72 | NR4A2 (0.47) | MAP2K1NR4A2CREBBP | |
| SCHEMBL25088402 | 0.70 | NR4A2 (0.49) | AXLMAP2K1NR4A2JAK3JAK2 | |
| SCHEMBL17818802 | 0.70 | NR4A2 (0.58) | AXLMAP2K1NR4A2JAK3JAK2 | |
| SCHEMBL3224390 | 0.68 | CHEK1 (0.50) | MAP2K1NR4A2JAK3JAK2 | |
| SCHEMBL9938466 | 0.68 | AXL (0.64) | AXLMAP2K1NR4A2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012078802-A1 | PREPARATION OF SUBSTITUTED-4,5-DIHYDROPYRROLO[4,3,2-de][2,6]NAPHTHYRIDIN-3(1H)-ONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-06-14 | — | — | WO | disclosed |