Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.48 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27139002 | 0.98 | SLC6A2 (0.47) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL29698898 | 0.98 | SLC6A2 (0.47) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| SCHEMBL3153964 | 0.85 | OPRM1 (0.52) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL9310981 | 0.84 | OPRM1 (0.46) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL2267897 | 0.84 | OPRM1 (0.51) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| SCHEMBL12369440 | 0.83 | OPRM1 (0.45) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| Tert-Butyl Formate SCHEMBL28025790 | 0.83 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| Hydrochloric Acid SCHEMBL9311016 | 0.82 | OPRM1 (0.44) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| SCHEMBL23232239 | 0.82 | OPRL1 (0.59) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 | |
| SCHEMBL31159130 | 0.78 | KDM1A (0.52) | SLC6A4SLC6A3SLC6A2OPRK1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. | 2024-02-29 | — | — | US | disclosed |
| WO-2022140290-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2022-06-30 | — | — | WO | disclosed |
| WO-2012076063-A1 | PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ROTTAPHARM S.P.A. (IT) | 2012-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067631-A1 | PYRAZOLE DERIVATIVES USEFUL AS NAMPT MODULATORS | NAMPT, NNT, NAPRT | SLC6A4 744/4885SLC6A3 725/4885SLC6A2 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.