SCHEMBL992357

O=C(N[C@H]1CCC[C@@](O)(C#Cc2cccc(Cl)c2)C1)c1cc(Cl)ccc1O.O=C(N[C@H]1CCC[C@@](O)(C#Cc2cccc(Cl)c2)C1)c1ccc(O)cc1

nearest known ligand 0.42

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	GRM5	P41594	11/20	0.42

▸	L3MBTL1	Q9Y468	1/20	0.41

▸	NPC1	O15118	1/20	0.41

▸	RAB9A	P51151	1/20	0.41

▸	ANO1	Q5XXA6	1/20	0.37

▸	P2RX1	P51575	3/20	0.37

▸	P2RX4	Q99571	1/20	0.37

▸	P2RX7	Q99572	1/20	0.37

▸	HSD11B1	P28845	2/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL1907158	0.94	GRM5 (0.46)	GRM5L3MBTL1NPC1RAB9AP2RX1
SCHEMBL1907156	0.94	GRM5 (0.46)	GRM5L3MBTL1NPC1RAB9AP2RX1
SCHEMBL2815651	0.94	GRM5 (0.46)	GRM5L3MBTL1NPC1RAB9AP2RX1
SCHEMBL2818567	0.93	L3MBTL1 (0.47)	GRM5L3MBTL1NPC1RAB9AHSD11B1
SCHEMBL990822	0.86	NPC1 (0.48)	GRM5L3MBTL1NPC1RAB9A
SCHEMBL990869	0.85	GRM5 (0.48)	GRM5L3MBTL1NPC1RAB9A
SCHEMBL992266	0.85	L3MBTL1 (0.46)	GRM5L3MBTL1NPC1RAB9AHSD11B1
SCHEMBL990340	0.84	L3MBTL1 (0.59)	GRM5L3MBTL1NPC1RAB9A
SCHEMBL990847	0.84	GRM5 (0.49)	GRM5L3MBTL1NPC1RAB9A
SCHEMBL990807	0.83	GRM5 (0.52)	GRM5L3MBTL1NPC1RAB9AHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2272509-A1	New Uses of metabotropic glutamate receptors	Novartis AG (CH)	2011-01-12	—	—	EP	disclosed