Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.83 |
| ▸ | ITK | Q08881 | 3/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | BLK | P51451 | 1/20 | 0.63 |
| ▸ | BMX | P51813 | 1/20 | 0.63 |
| ▸ | JAK3 | P52333 | 1/20 | 0.63 |
| ▸ | CTSC | P53634 | 1/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.63 |
| ▸ | BTK | Q06187 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.63 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.63 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.63 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.63 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19360703 | 0.93 | EGFR (0.72) | EGFRITKPLK4GAKNUAK1 | |
| SCHEMBL9923757 | 0.92 | EGFR (0.82) | EGFRITKBTK | |
| SCHEMBL5585132 | 0.91 | EGFR (1.00) | EGFRITKPLK4GAKNUAK1 | |
| SCHEMBL10064985 | 0.91 | EGFR (0.81) | EGFRITKPLK4GAKNUAK1 | |
| SCHEMBL9893595 | 0.91 | EGFR (1.00) | EGFRITKPLK4GAKNUAK1 | |
| SCHEMBL9923761 | 0.89 | EGFR (0.83) | EGFRITKBTK | |
| SCHEMBL9923765 | 0.89 | EGFR (0.82) | EGFRITKBTK | |
| SCHEMBL5585054 | 0.88 | EGFR (1.00) | EGFR | |
| SCHEMBL19360705 | 0.88 | EGFR (0.74) | EGFRITKPLK4GAKNUAK1 | |
| SCHEMBL9923758 | 0.87 | EGFR (0.82) | EGFRITKBTKERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2018-03-15 | — | — | US | disclosed |
| US-9765038-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-09-19 | — | — | US | disclosed |
| US-20160130236-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | BRISTOL-MYERS SQUIBB COMPANY | 2016-05-12 | — | — | US | disclosed |
| US-9238629-B2 | Heteroaryl compounds and uses thereof | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-01-19 | — | — | US | disclosed |
| US-20120149722-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072687-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ITK 2697/4885PLK4 3209/4885 |
| US-20160130236-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ITK 2697/4885PLK4 3209/4885 |
| US-20120149722-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | EGFR 1981/4885ITK 2697/4885PLK4 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.