Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.72 |
| ▸ | BTK | Q06187 | 2/20 | 0.63 |
| ▸ | ITK | Q08881 | 2/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | GAK | O14976 | 1/20 | 0.63 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | BLK | P51451 | 1/20 | 0.63 |
| ▸ | BMX | P51813 | 1/20 | 0.63 |
| ▸ | JAK3 | P52333 | 1/20 | 0.63 |
| ▸ | CTSC | P53634 | 1/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.63 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.63 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.63 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.63 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.63 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.63 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9923760 | 0.93 | EGFR (0.83) | EGFRBTKITKPLK4GAK | |
| SCHEMBL9923757 | 0.92 | EGFR (0.82) | EGFRBTKITK | |
| SCHEMBL24784922 | 0.92 | EGFR (0.86) | EGFRBTKITKPLK4GAK | |
| SCHEMBL9923761 | 0.89 | EGFR (0.83) | EGFRBTKITK | |
| SCHEMBL9923765 | 0.89 | EGFR (0.82) | EGFRBTKITK | |
| SCHEMBL19360705 | 0.88 | EGFR (0.74) | EGFRBTKITKPLK4GAK | |
| SCHEMBL21338057 | 0.86 | EGFR (0.72) | EGFRBTKITKPLK4GAK | |
| SCHEMBL15130588 | 0.86 | EGFR (0.85) | EGFRBTKITKPLK4GAK | |
| SCHEMBL19360697 | 0.86 | EGFR (0.74) | EGFRBTKITKERBB4 | |
| SCHEMBL9945445 | 0.85 | EGFR (0.86) | EGFRBTKITKPLK4GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765038-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2017-09-19 | — | — | US | disclosed |