Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1978329 | 0.83 | KDM4E (0.48) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5342115 | 0.79 | KDM4E (0.62) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL12594101 | 0.75 | KDM4E (0.64) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL12594177 | 0.74 | KDM4E (0.56) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL6178269 | 0.74 | KDM4E (0.63) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL20931746 | 0.73 | KDM4E (0.79) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL22281530 | 0.72 | NOS2 (0.54) | KDM4EMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6418163 | 0.71 | KMT2A (0.52) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL22548629 | 0.71 | KDM4E (0.55) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL6178262 | 0.71 | KDM4E (0.59) | KDM4EPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |