SCHEMBL9925475

SCHEMBL9925475

CC/C(N)=N\C(=O)c1ccc2nccc(-c3cc(Cl)c(F)cc3F)c2c1

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HTR5A P47898 16/20 0.47
AAK1 Q2M2I8 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9907802 0.89 HTR5A (0.59) HTR5A
SCHEMBL9907370 0.79 MAPKAPK2 (0.40) HTR5A
SCHEMBL15500547 0.79 HTR5A (0.39) HTR5A
SCHEMBL9907367 0.78 HTT (0.45)
SCHEMBL9907804 0.77 HTR5A (0.54) HTR5A
SCHEMBL9907796 0.76 HTR5A (0.59) HTR5A
SCHEMBL12874631 0.75 HTR5A (0.52) HTR5A
SCHEMBL9907797 0.74 HTR5A (0.64) HTR5A
SCHEMBL9907816 0.74 HTR5A (0.53) HTR5A
SCHEMBL9907845 0.74 HTR5A (0.61) HTR5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2463276-A1 NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE Astellas Pharma Inc. (JP) 2012-06-13 EP disclosed