Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.85 |
| ▸ | KDR | P35968 | 6/20 | 0.68 |
| ▸ | BRAF | P15056 | 4/20 | 0.67 |
| ▸ | RET | P07949 | 3/20 | 0.67 |
| ▸ | GSK3B | P49841 | 2/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | ABL1 | P00519 | 2/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | KIT | P10721 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.67 |
| ▸ | FLT1 | P17948 | 2/20 | 0.67 |
| ▸ | MAOA | P21397 | 2/20 | 0.67 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.67 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.67 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29918250 | 0.92 | RAF1 (1.00) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL548133 | 0.92 | RAF1 (1.00) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL9926366 | 0.88 | RAF1 (0.85) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL16628137 | 0.86 | RAF1 (0.79) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL8164609 | 0.86 | RAF1 (0.63) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL6123385 | 0.85 | RAF1 (0.77) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL3405012 | 0.84 | RAF1 (0.85) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL939087 | 0.84 | RAF1 (0.85) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL3408496 | 0.84 | RAF1 (0.85) | RAF1KDRBRAFRETGSK3B | |
| SCHEMBL3539204 | 0.84 | RAF1 (0.81) | RAF1KDRBRAFRETGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636585-B2 | DIARYL UREAS WITH KINASE INHIBITING ACTIVITY | BAYER HEALTHCARE LLC (US) | 2012-06-13 | — | — | EP | disclosed |