Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 10/20 | 0.79 |
| ▸ | BRAF | P15056 | 7/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.69 |
| ▸ | KDR | P35968 | 3/20 | 0.66 |
| ▸ | ARAF | P10398 | 2/20 | 0.65 |
| ▸ | GSK3B | P49841 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | CIT | O14578 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13946086 | 0.90 | KDR (0.80) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL13946089 | 0.90 | RAF1 (0.67) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL16628076 | 0.89 | RAF1 (0.81) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL548133 | 0.88 | RAF1 (1.00) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL29918250 | 0.88 | RAF1 (1.00) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL9926369 | 0.86 | RAF1 (0.85) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL29242634 | 0.83 | RAF1 (0.84) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL6123385 | 0.83 | RAF1 (0.77) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL28611102 | 0.83 | RAF1 (0.83) | RAF1BRAFHDAC1HDAC3HDAC4 | |
| SCHEMBL15140606 | 0.83 | BRAF (0.64) | RAF1BRAFHDAC1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015051149-A1 | SORAFENIB ANALOGS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-04-09 | — | — | WO | disclosed |