Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 11/20 | 0.57 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624434 | 0.91 | SIRT1 (0.60) | SIRT1ABCG2MAPK1ABCB1PDE4D | |
| SCHEMBL2624690 | 0.83 | SIRT1 (0.72) | SIRT1 | |
| SCHEMBL2624435 | 0.80 | SIRT1 (0.71) | SIRT1MAPK1PDCD1CD274 | |
| SCHEMBL2624433 | 0.80 | SIRT1 (0.85) | SIRT1ABCG2MAPK1ABCB1PDE4D | |
| SCHEMBL2624436 | 0.75 | SIRT1 (0.50) | SIRT1ABCG2PKMABCB1PDE4D | |
| SCHEMBL2624513 | 0.74 | SIRT1 (0.87) | SIRT1 | |
| SCHEMBL2624432 | 0.74 | TP53 (0.69) | SIRT1ABCG2MAPK1PKMABCB1 | |
| SCHEMBL2740381 | 0.74 | SIRT1 (0.80) | SIRT1CHEK1 | |
| SCHEMBL2740427 | 0.73 | SIRT1 (0.68) | SIRT1MAPK1 | |
| SCHEMBL20893167 | 0.72 | SIRT1 (0.88) | SIRT1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955077-B1 | MASS SPECTROMETRY ASSAYS FOR ACETYLTRANSFERASE/DEACETYLASE ACTIVITY | SIRTRIS PHARMACEUTICALS INC (US) | 2012-06-13 | — | — | EP | disclosed |