Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL992715 | 1.00 | PRCP (0.38) | PRCPRAB9AS1PR2KMT2AGAA | |
| SCHEMBL935321 | 0.86 | PDGFRB (0.40) | PRCPKMT2APDGFRBPDGFRATDP1 | |
| SCHEMBL935319 | 0.86 | PDGFRB (0.40) | PRCPKMT2APDGFRBPDGFRATDP1 | |
| SCHEMBL935044 | 0.82 | CDC7 (0.46) | KMT2APDGFRBPDGFRACDC7GSK3B | |
| SCHEMBL6127259 | 0.80 | CDK2 (0.46) | KMT2APDGFRBPDGFRACDC7GSK3B | |
| SCHEMBL936047 | 0.79 | KMT2A (0.53) | KMT2APDGFRBPDGFRATDP1CDC7 | |
| SCHEMBL1048369 | 0.78 | PRCP (0.31) | PRCPRAB9AHCAR3PDGFRBPDGFRA | |
| SCHEMBL1048368 | 0.77 | IDH1 (0.32) | HCAR3PDGFRBPDGFRACDC7GSK3B | |
| SCHEMBL992958 | 0.76 | ADORA3 (0.39) | PRCPRAB9ATDP1CDC7GSK3B | |
| SCHEMBL992960 | 0.76 | ADORA3 (0.39) | PRCPRAB9ATDP1CDC7GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |