⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060577 | 0.69 | — | — | |
| SCHEMBL12868887 | 0.69 | — | — | |
| SCHEMBL2953440 | 0.67 | CYP1A2 (0.30) | — | |
| SCHEMBL28099752 | 0.67 | — | — | |
| SCHEMBL3501288 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL7033913 | 0.65 | — | — | |
| SCHEMBL18896370 | 0.65 | — | — | |
| SCHEMBL14330446 | 0.65 | TSHR (0.33) | — | |
| SCHEMBL336818 | 0.63 | ALDH1A1 (0.30) | — | |
| SCHEMBL25765190 | 0.63 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983077-A1 | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM | Alnylam Pharmaceuticals, Inc. (US) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020257194-A1 | DELIVERY OF OLIGONUCLEOTIDES TO THE STRIATUM | ALNYLAM PHARMACEUTICALS, INC. (US) | 2020-12-24 | — | — | WO | disclosed |
| EP-3262181-A1 | METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS | Ionis Pharmaceuticals, Inc. (US) | 2018-01-03 | — | — | EP | disclosed |
| EP-3119789-A1 | BICYCLIC CARBOCYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | Ionis Pharmaceuticals, Inc. (US) | 2017-01-25 | — | — | EP | disclosed |
| WO-2016137923-A1 | METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS | IONIS PHARMACEUTICALS, INC. (US) | 2016-09-01 | — | — | WO | disclosed |
| EP-2951191-A2 | METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS | Isis Pharmaceuticals, Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| WO-2015142910-A1 | BICYCLIC CARBOCYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2015-09-24 | — | — | WO | disclosed |
| WO-2015061246-A1 | METHOD FOR SOLUTION PHASE DETRITYLATION OF OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2015-04-30 | — | — | WO | disclosed |
| EP-2834257-A1 | TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | Universität Bern (CH) | 2015-02-11 | — | — | EP | disclosed |
| WO-2014120861-A2 | METHOD OF PREPARING OLIGOMERIC COMPOUNDS USING MODIFIED COUPLING PROTOCOLS | ISIS PHARMACEUTICALS, INC. (US) | 2014-08-07 | — | — | WO | disclosed |
| WO-2011156202-A1 | SUBSTITUTED 2 '-AMINO AND 2 '-THIO-BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2011-12-15 | — | — | WO | disclosed |
| WO-2011156278-A1 | BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2011-12-15 | — | — | WO | disclosed |
| WO-2011133871-A2 | 5'-END DERIVATIVES | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011115818-A1 | 5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| EP-2358397-A2 | 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom | Isis Pharmaceuticals, Inc. (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2011085102-A1 | BASE MODIFIED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011017521-A2 | BICYCLIC CYCLOHEXOSE NUCLEIC ACID ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2011005860-A2 | 5' PHOSPHATE MIMICS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2010101951-A1 | NUCLEIC ACID CHEMICAL MODIFICATIONS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010048549-A2 | 5' AND 2' BIS-SUBSTITUTED NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |