Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA7 | P43166 | 3/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 2/20 | 0.32 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 2/20 | 0.31 |
| ▸ | FAP | Q12884 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15083704 | 0.94 | CA1 (0.48) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL3903305 | 0.83 | CA1 (0.42) | CA1CA2CA12CA7CA14 | |
| SCHEMBL3904237 | 0.82 | CA1 (0.45) | CA1CA2CA12CA7CA14 | |
| SCHEMBL18747653 | 0.78 | S1PR4 (0.36) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL30675060 | 0.78 | ACHE (0.35) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL18747676 | 0.74 | KDM4E (0.39) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL18747649 | 0.72 | KDM4E (0.42) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL18747702 | 0.72 | KDM4E (0.42) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL161732 | 0.72 | KDM4E (0.42) | CA1CA2TAAR1CA12CA7 | |
| SCHEMBL18747671 | 0.72 | KDM4E (0.42) | CA1CA2TAAR1CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |