Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.45 |
| ▸ | TNNI3K | Q59H18 | 10/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9898706 | 0.89 | CDC7 (0.43) | BRAFTNNI3KIRAK4KDRPRKD1 | |
| SCHEMBL9896599 | 0.84 | JAK3 (0.55) | JAK3 | |
| Hydrochloric Acid SCHEMBL9896597 | 0.83 | JAK3 (0.55) | JAK3 | |
| SCHEMBL9928298 | 0.81 | BRAF (0.36) | BRAFTNNI3KIRAK4KDRPRKD1 | |
| SCHEMBL9928279 | 0.81 | LRRK2 (0.39) | BRAFTNNI3KPRKD1ROCK2EGFR | |
| SCHEMBL9928319 | 0.81 | TTBK1 (0.42) | BRAFTNNI3KKDRPRKD1CDC7 | |
| SCHEMBL9928260 | 0.80 | EGFR (0.44) | KDREGFR | |
| SCHEMBL16963582 | 0.79 | MKNK1 (0.60) | CDC7EGFRJAK3 | |
| SCHEMBL13471645 | 0.78 | PRKD1 (0.37) | BRAFTNNI3KIRAK4KDRPRKD1 | |
| SCHEMBL9928300 | 0.77 | KDR (0.34) | BRAFTNNI3KKDRPRKD1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | BRAF 131/4885TNNI3K 372/4885IRAK4 1112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.