Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.39 |
| ▸ | MERTK | Q12866 | 4/20 | 0.39 |
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | BRAF | P15056 | 3/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 7/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904088 | 0.93 | EGFR (0.46) | EGFRERBB2KDR | |
| SCHEMBL9928291 | 0.86 | EGFR (0.53) | BRAFTNNI3KEGFRERBB2KDR | |
| SCHEMBL9928293 | 0.85 | ERBB2 (0.44) | BRAFTNNI3KEGFRERBB2DRD2 | |
| SCHEMBL9897560 | 0.83 | BTK (0.51) | KDR | |
| SCHEMBL9928280 | 0.82 | EGFR (0.54) | EGFRERBB2KDR | |
| SCHEMBL9928282 | 0.82 | EGFR (0.53) | BRAFTNNI3KEGFRERBB2LRRK2 | |
| SCHEMBL9928303 | 0.82 | TTBK1 (0.45) | AXLMERTKMETBRAFTNNI3K | |
| SCHEMBL9928279 | 0.81 | LRRK2 (0.39) | AXLMERTKMETBRAFTNNI3K | |
| SCHEMBL9943134 | 0.81 | EGFR (0.46) | EGFRERBB2KDR | |
| SCHEMBL9928294 | 0.81 | EGFR (0.38) | MERTKBRAFTNNI3KEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | UBE INDUSTRIES, LTD. (JP) | 2012-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120149902-A1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE | ERBB2, EGFR, FGFR1 | AXL 274/4885MERTK 810/4885MET 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.