SCHEMBL9928680

SCHEMBL9928680

CCOC(=O)c1nnn(-c2ccccc2F)c1C1CCCC1.O=C(O)c1nnn(-c2ccccc2F)c1C1CCCC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.50
ALOX12 P18054 1/20 0.50
NPSR1 Q6W5P4 2/20 0.49
ALDH1A1 P00352 5/20 0.48
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
GAA P10253 1/20 0.43
TSHR P16473 1/20 0.43
MAPT P10636 2/20 0.43
SLC5A1 P13866 3/20 0.41
SLC5A2 P31639 3/20 0.41
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
HPGD P15428 2/20 0.40
POLB P06746 1/20 0.40
MAPK1 P28482 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
ELANE P08246 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3455998 0.96 NPSR1 (0.53) TP53ALOX12NPSR1ALDH1A1MEN1
SCHEMBL3455812 0.92 NPSR1 (0.55) TP53ALOX12NPSR1ALDH1A1MEN1
SCHEMBL3456037 0.91 TP53 (0.47) TP53ALOX12NPSR1ALDH1A1MEN1
SCHEMBL3455582 0.88 DHODH (0.41) ALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL3455348 0.87 NPSR1 (0.50) TP53ALOX12NPSR1ALDH1A1MEN1
SCHEMBL3455921 0.87 TP53 (0.47) TP53ALOX12NPSR1ALDH1A1MEN1
SCHEMBL3463266 0.84 HTT (0.41) ALDH1A1GAA
SCHEMBL3758629 0.82 NPSR1 (0.49) TP53ALOX12NPSR1ALDH1A1MEN1
SCHEMBL25767433 0.80 TP53 (0.67) TP53ALOX12NPSR1ALDH1A1KMT2A
Bicarbonate SCHEMBL3457190 0.79 NPSR1 (0.46) TP53ALOX12NPSR1ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8202856-B2 Triazole oxadiazoles derivatives MERCK SERONO SA (CH) 2012-06-19 US disclosed