⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116740 | 0.87 | — | — | |
| Ethyne SCHEMBL7907470 | 0.72 | — | — | |
| SCHEMBL31402443 | 0.67 | — | — | |
| SCHEMBL31463359 | 0.61 | — | — | |
| SCHEMBL509151 | 0.58 | — | — | |
| SCHEMBL687144 | 0.58 | — | — | |
| Ethyne SCHEMBL10836712 | 0.58 | — | — | |
| SCHEMBL8897699 | 0.54 | ALDH1A1 (0.30) | — | |
| Ethyne SCHEMBL6050547 | 0.53 | — | — | |
| SCHEMBL2184 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359532-A | Method for synthesizing fluorine-containing substituted aza-aryl tertiary alcohol by using asymmetric olefin difunctional one-pot method under catalysis of chiral phosphoric acid | 浙江工业大学 | 2024-07-19 | — | — | CN | claimed |
| CN-117777179-A | Synthesis process of hexakis (trimethylsilyl ethynyl) benzene | 山东大学 | 2024-03-29 | — | — | CN | claimed |
| CN-117003632-A | Method for preparing 5-bromo-4, 5-tetrafluorovaleric acid | 上海恩氟佳科技有限公司 | 2023-11-07 | — | — | CN | claimed |
| WO-2021103795-A1 | OXIDIZED RING BELT [8] AROMATIC HYDROCARBON DERIVATIVE AND PREPARATION METHOD THEREFOR | 清华大学 | 2021-06-03 | — | — | WO | claimed |
| CN-109280220-B | Modified attapulgite, preparation method thereof and application of modified attapulgite in low-smoke halogen-free flame-retardant cable | 江苏宝源高新电工有限公司 | 2020-05-12 | — | — | CN | claimed |
| CN-103059034-B | Methods for synthesizing securinine natural products flueggine A, norsecurinine, virosaine B and allonorsecurinine | UNIV PEKING SHENZHEN GRAD SCHO | 2015-03-25 | — | — | CN | claimed |
| CN-103059034-A | Methods for synthesizing securinine natural products flueggine A, norsecurinine, virosaine B and allonorsecurinine | UNIV PEKING SHENZHEN GRAD SCHO | 2013-04-24 | — | — | CN | claimed |
| US-12331036-B2 | Heterocyclic RIP1 kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2025-06-17 | — | — | US | disclosed |
| EP-4025572-B1 | HETEROCYCLIC RIP1 KINASE INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2025-05-07 | — | — | EP | disclosed |
| EP-4025574-B1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS INC (US) | 2025-05-07 | — | — | EP | disclosed |
| US-12156880-B2 | Heterocyclic RIP1 kinase inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2024-12-03 | — | — | US | disclosed |
| US-20240368119-A1 | RIP1 INHIBITORY COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME | RIGEL PHARMACEUTICALS, INC. | 2024-11-07 | — | — | US | disclosed |
| CN-115397824-B | Process for preparing COT inhibitor compounds | 吉利德科学公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-101309586-A | Thiazole compounds as fungicides | BAYER CROPSCIENCE AG (DE) | 2008-11-19 | — | — | CN | disclosed |
| CN-100402497-C | Fluorinated vitamin D3 analogs | HOFFMANN LA ROCHE (CH) | 2008-07-16 | — | — | CN | disclosed |
| EP-1490060-A1 | ANTIDIABETIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6696474-B2 | SUCH AS 8-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-2-PYRROL-1-YL-OCT-4-YNOIC ACID; NONINSULIN DEPENDENT DIABETES MELLITUS | WARNER LAMBERT CO. LLC. | 2004-02-24 | — | — | US | disclosed |
| US-20030220381-A1 | ANTIDIABETIC AGENTS | WARNER-LAMBERT COMPANY, LLC | 2003-11-27 | — | — | US | disclosed |
| WO-2003082276-A1 | ANTIDIABETIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2003-10-09 | — | — | WO | disclosed |
| CN-1172801-A | Fluorinated vitamin D3 analogs | HOFFMANN LA ROCHE (CH) | 1998-02-11 | — | — | CN | disclosed |