Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20054876 | 0.90 | GRIN2B (0.41) | USP2SMN1; SMN2CTSKEPHX1GRIN2B | |
| SCHEMBL193269 | 0.90 | GRIN2B (0.41) | USP2SMN1; SMN2CTSKEPHX1GRIN2B | |
| SCHEMBL1839800 | 0.89 | GRIN2B (0.38) | USP2SMN1; SMN2CTSKEPHX1GRIN2B | |
| SCHEMBL7227763 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2CTSKGRIN2BGRIN2C | |
| SCHEMBL4249117 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2CTSKGRIN2BGRIN2C | |
| SCHEMBL6078246 | 0.77 | USP2 (0.40) | USP2SMN1; SMN2CTSKGRIN2BGRIN2C | |
| SCHEMBL539753 | 0.74 | GRIN2B (0.32) | USP2SMN1; SMN2GRIN2BGRIN2CCHRM2 | |
| SCHEMBL751694 | 0.74 | BUB1 (0.35) | USP2SMN1; SMN2GRIN2BGRIN2CCHRM2 | |
| SCHEMBL8240701 | 0.74 | USP2 (0.43) | USP2SMN1; SMN2CTSKEPHX1GRIN2B | |
| SCHEMBL2246036 | 0.74 | GRIN2B (0.43) | USP2SMN1; SMN2CTSKEPHX1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |
| WO-2011008915-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-01-20 | — | — | WO | disclosed |