Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL502555 | 0.80 | GRIN2B (0.33) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL705951 | 0.80 | GRIN2B (0.33) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL6919845 | 0.80 | GRIN2B (0.33) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL992886 | 0.74 | USP2 (0.39) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL15116517 | 0.74 | GRIN2B (0.33) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL31645901 | 0.73 | NR1H2 (0.34) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL20054625 | 0.73 | GRIN2B (0.32) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL28935456 | 0.72 | GPR119 (0.37) | — | |
| SCHEMBL193269 | 0.72 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 | |
| SCHEMBL20054876 | 0.72 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414350-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010117635-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-10-14 | — | — | WO | disclosed |
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |