Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 4/20 | 0.58 |
| ▸ | HTR1A | P08908 | 10/20 | 0.57 |
| ▸ | DRD2 | P14416 | 10/20 | 0.57 |
| ▸ | HTR2A | P28223 | 10/20 | 0.57 |
| ▸ | DRD3 | P35462 | 9/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15190286 | 0.85 | HTR1A (0.54) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL993493 | 0.83 | SCD (0.58) | SCDDRD2DRD3 | |
| SCHEMBL1046444 | 0.80 | HCAR2 (0.54) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL992629 | 0.80 | SCD (0.57) | SCD | |
| SCHEMBL993242 | 0.80 | SCD (0.64) | SCD | |
| SCHEMBL2468860 | 0.79 | SCD (0.65) | SCD | |
| SCHEMBL17579312 | 0.78 | HTR1A (0.75) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL17579610 | 0.78 | HTR1A (0.75) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL17579308 | 0.78 | HTR1A (0.75) | HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL5596966 | 0.78 | SCD (0.72) | SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026360-B2 | Substituted pyridazines as stearoyl-CoA desaturase inhibitors | XENON PHARMACEUTICALS INC. (CA) | 2011-09-27 | — | — | US | claimed |
| EP-2269610-A2 | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | Xenon Pharmaceuticals Inc. (CA) | 2011-01-05 | — | — | EP | claimed |
| US-8026360-B2 | Substituted pyridazines as stearoyl-CoA desaturase inhibitors | XENON PHARMACEUTICALS INC. (CA) | 2011-09-27 | — | — | US | disclosed |
| EP-2269610-A2 | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors | Xenon Pharmaceuticals Inc. (CA) | 2011-01-05 | — | — | EP | disclosed |