Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PIR | O00625 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.37 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.37 |
| ▸ | OXSR1 | O95747 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | FES | P07332 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9931343 | 0.88 | BRAF (0.43) | BRAFKCNH2RAF1CYP2C9KDM4E | |
| SCHEMBL1462961 | 0.88 | BRAF (0.49) | BRAFKCNH2RAF1CYP2C9 | |
| SCHEMBL9930589 | 0.87 | BRAF (0.54) | BRAFRAF1CYP2C9BMPR1BPLK4 | |
| SCHEMBL9930989 | 0.86 | CYP3A4 (0.51) | BRAFRAF1CYP2C9BMPR1BPLK4 | |
| SCHEMBL1462104 | 0.85 | BRAF (0.47) | BRAFKCNH2RAF1CYP2C9BMPR1B | |
| SCHEMBL9930872 | 0.84 | PSIP1 (0.46) | BRAFRAF1CYP2C9BMPR1BPLK4 | |
| SCHEMBL9930275 | 0.82 | BRAF (0.48) | BRAFRAF1CYP2C9BMPR1BPLK4 | |
| SCHEMBL1462138 | 0.81 | BRAF (0.46) | BRAFKCNH2RAF1CYP2C9 | |
| SCHEMBL9931434 | 0.80 | BRAF (0.49) | BRAFRAF1CYP2C9BMPR1BPLK4 | |
| SCHEMBL1462229 | 0.79 | BRAF (0.42) | BRAFKCNH2RAF1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | claimed |
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130018033-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | BRAF 1/4885KCNH2 4554/4885RAF1 2/4885 |
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | BRAF 1/4885KCNH2 4554/4885RAF1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.