Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 17/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 14/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 11/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 11/20 | 0.55 |
| ▸ | TSHR | P16473 | 9/20 | 0.55 |
| ▸ | LMNA | P02545 | 9/20 | 0.53 |
| ▸ | USP2 | O75604 | 9/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930862 | 0.92 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL9930489 | 0.83 | KDM4C (0.53) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL1461787 | 0.82 | AURKA (0.71) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL30401701 | 0.82 | AURKA (0.71) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL9930459 | 0.81 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL24399556 | 0.80 | AURKA (0.55) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL30402343 | 0.80 | AURKA (0.55) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL27902365 | 0.80 | AURKA (0.55) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL9930247 | 0.79 | CYP1A2 (0.50) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 | |
| SCHEMBL24399745 | 0.78 | AURKA (0.71) | CYP1A2CYP3A4CYP2C19CYP2D6CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011025940-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2011-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | CYP1A2 2189/4885CYP3A4 2785/4885CYP2C19 2795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.