Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 11/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.35 |
| ▸ | USP2 | O75604 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930889 | 0.81 | KDR (0.35) | CYP1A2CYP3A4CYP2C19CYP2D6HSD17B10 | |
| SCHEMBL9930497 | 0.79 | BRAF (0.35) | LMNAAURKAAURKBMAPTMEN1 | |
| SCHEMBL9931391 | 0.76 | BRAF (0.42) | LMNAMAPTMEN1KMT2ABRAF | |
| SCHEMBL9930834 | 0.75 | BRAF (0.49) | CYP2C9BRAF | |
| SCHEMBL9930333 | 0.73 | BRAF (0.49) | CYP2C9BRAF | |
| SCHEMBL9930459 | 0.72 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19CYP2D6HSD17B10 | |
| SCHEMBL9930556 | 0.72 | BRAF (0.48) | MAPK1CYP2C9KDM4EBRAF | |
| SCHEMBL9930341 | 0.72 | BRAF (0.48) | CYP2C9BRAF | |
| SCHEMBL9930607 | 0.72 | MAPT (0.56) | CYP1A2CYP3A4CYP2C19CYP2D6HSD17B10 | |
| SCHEMBL9930345 | 0.72 | BRAF (0.37) | CYP3A4CYP2C19MAPK1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | CYP1A2 2189/4885CYP3A4 2785/4885CYP2C19 2795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.