Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9930459 | 0.89 | CYP1A2 (0.48) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL1460958 | 0.79 | MAPT (0.72) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL21174131 | 0.79 | MAPT (0.60) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL1460973 | 0.78 | MAPT (0.64) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL23283350 | 0.75 | MAPT (0.47) | MAPTLMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29971212 | 0.75 | MAPT (0.47) | MAPTLMNACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9930862 | 0.75 | CYP1A2 (0.55) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL9930247 | 0.74 | CYP1A2 (0.50) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL24399596 | 0.74 | AURKA (0.56) | MAPTAURKARPS6KB1LMNACYP1A2 | |
| SCHEMBL24399771 | 0.73 | KDM4C (0.52) | MAPTAURKARPS6KB1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157439-A1 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | BRAF, RAF1, ARAF | MAPT 1082/4885AURKA 1013/4885RPS6KB1 315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.