Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.54 |
| ▸ | PLK1 | P53350 | 6/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
| ▸ | AKT1 | P31749 | 2/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239249 | 0.83 | KDR (0.58) | KDRPTK2PLK1METAP2METAP1 | |
| SCHEMBL14764766 | 0.79 | KDR (0.61) | KDRPTK2PLK1METAP2METAP1 | |
| SCHEMBL172248 | 0.76 | CYP19A1 (0.61) | KDRPTK2PLK1METAP2METAP1 | |
| SCHEMBL9932266 | 0.76 | MEN1 (0.58) | KDRPTK2PLK1METAP2METAP1 | |
| SCHEMBL29520302 | 0.74 | KDR (0.63) | KDRPTK2PLK1METAP2METAP1 | |
| SCHEMBL13033399 | 0.72 | SMO (0.47) | GRM2KDM4EOPRM1OPRD1HRH4 | |
| SCHEMBL1171430 | 0.72 | MEN1 (0.69) | METAP2METAP1MEN1KMT2AKDM4E | |
| SCHEMBL4814275 | 0.71 | CYP19A1 (0.56) | KDRPTK2PLK1METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7175864 | 0.71 | MEN1 (0.60) | KDRPTK2PLK1METAP2METAP1 | |
| Hydrochloric Acid SCHEMBL7174476 | 0.71 | MEN1 (0.60) | KDRPTK2PLK1METAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | KDR 1623/4885PTK2 3203/4885PLK1 1064/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.