Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 7/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.57 |
| ▸ | PLK1 | P53350 | 4/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 6/20 | 0.54 |
| ▸ | TP53 | P04637 | 5/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7173200 | 0.96 | MEN1 (0.60) | MEN1KMT2AMETAP2METAP1KDR | |
| Hydrochloric Acid SCHEMBL7176548 | 0.96 | MEN1 (0.60) | MEN1KMT2AMETAP2METAP1KDR | |
| Hydrochloric Acid SCHEMBL7183099 | 0.96 | MEN1 (0.60) | MEN1KMT2AMETAP2METAP1KDR | |
| Hydrochloric Acid SCHEMBL7178625 | 0.96 | MEN1 (0.60) | MEN1KMT2AMETAP2METAP1KDR | |
| Hydrochloric Acid SCHEMBL7173513 | 0.96 | MEN1 (0.60) | MEN1KMT2AMETAP2METAP1KDR | |
| Hydrochloric Acid SCHEMBL7175864 | 0.96 | MEN1 (0.60) | MEN1KMT2AMETAP2METAP1KDR | |
| SCHEMBL1273984 | 0.96 | METAP2 (0.61) | MEN1KMT2AMETAP2METAP1KDR | |
| SCHEMBL29779792 | 0.96 | METAP2 (0.61) | MEN1KMT2AMETAP2METAP1KDR | |
| SCHEMBL4814275 | 0.89 | CYP19A1 (0.56) | MEN1KMT2AMETAP2METAP1KDR | |
| SCHEMBL1533891 | 0.85 | METAP2 (0.57) | MEN1KMT2AMETAP2METAP1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367069-A1 | Process for homo-or copolymerization of conjugated diens | DOW GLOBAL TECHNOLOGIES INC. (US) | 2003-12-03 | — | — | EP | disclosed |