Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 7/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9931941 | 0.93 | OPRM1 (0.44) | MEN1KMT2ACYP2C9SMOOPRM1 | |
| SCHEMBL9931893 | 0.93 | MEN1 (0.41) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9933208 | 0.90 | CYP2C9 (0.41) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9968394 | 0.90 | PDE10A (0.41) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9932360 | 0.85 | MAP4K4 (0.44) | MEN1KMT2ACYP2C9SMO | |
| SCHEMBL9931793 | 0.85 | PDE10A (0.39) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9932029 | 0.84 | MEN1 (0.44) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9932899 | 0.84 | MEN1 (0.44) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9931884 | 0.84 | MEN1 (0.44) | PDE10AMEN1KMT2ACYP2C9SMO | |
| SCHEMBL9932946 | 0.84 | CYP2C9 (0.41) | PDE10AMEN1KMT2ACYP2C9SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER INC. (US) | 2012-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157471-A1 | BENZIMIDAZOLE DERIVATIVES | SMO, RB1, GLI1 | PDE10A 1879/4885MEN1 1168/4885KMT2A 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.