Sugi Predict

Sugi Predict / Compounds / SCHEMBL9932428

SCHEMBL9932428

SCHEMBL9932428

COc1ccc2c(O)cc3c(c2c1)-c1ccccc1C3(C)C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ GAA P10253 1/20 0.43
▸ PDK2 Q15119 4/20 0.41
▸ PGR P06401 2/20 0.39
▸ HSP90AA1 P07900 1/20 0.36
▸ AR P10275 2/20 0.36
▸ HDAC4 P56524 2/20 0.35
▸ HDAC2 Q92769 2/20 0.35
▸ HDAC8 Q9BY41 2/20 0.35
▸ ALOX15 P16050 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ CDK1 P06493 2/20 0.35
▸ CCNB1 P14635 2/20 0.35
▸ GSK3B P49841 2/20 0.35
▸ CCNB2 O95067 1/20 0.35
▸ GSK3A P49840 1/20 0.35
▸ CDK5 Q00535 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8513625 0.95 MEN1 (0.43) MEN1KMT2AGAAPDK2PGR
SCHEMBL12424597 0.90 PDK2 (0.42) MEN1KMT2AGAAPDK2PGR
SCHEMBL9898233 0.88 MEN1 (0.45) MEN1KMT2AGAAPDK2PGR
SCHEMBL1813707 0.85 MEN1 (0.42) MEN1KMT2AGAAPDK2PGR
SCHEMBL10018176 0.85 MEN1 (0.44) MEN1KMT2AGAAPDK2PGR
SCHEMBL9898302 0.85 HSP90AA1 (0.44) MEN1KMT2AGAAPDK2HSP90AA1
SCHEMBL16301275 0.84 PDK2 (0.38) MEN1KMT2AGAAPDK2PGR
SCHEMBL165110 0.83 PDK2 (0.40) MEN1KMT2AGAAPDK2PGR
SCHEMBL1010429 0.83 ALK (0.40) MEN1KMT2AGAAPDK2ALDH1A1
SCHEMBL30125362 0.83 PDK2 (0.40) MEN1KMT2AGAAPDK2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9073838-B2 Method of making indeno-fused naphthol materials TRANSITIONS OPTICAL, INC. (US) 2015-07-07 — — US disclosed
US-9073838-B2 Method of making indeno-fused naphthol materials TRANSITIONS OPTICAL, INC. (US) 2015-07-07 — — US disclosed
US-9073838-B2 Method of making indeno-fused naphthol materials TRANSITIONS OPTICAL, INC. (US) 2015-07-07 — — US disclosed
US-20140364618-A1 Method of Making Indeno-Fused Naphthol Materials TRANSITIONS OPTICALS, INC. (US) 2014-12-11 — — US disclosed
US-20140364618-A1 Method of Making Indeno-Fused Naphthol Materials TRANSITIONS OPTICALS, INC. (US) 2014-12-11 — — US disclosed
US-20140364618-A1 Method of Making Indeno-Fused Naphthol Materials TRANSITIONS OPTICALS, INC. (US) 2014-12-11 — — US disclosed
US-8765978-B2 Method of making indeno-fused naphthol materials TRANSITIONS OPTICAL, INC. (US) 2014-07-01 — — US disclosed
US-20120157696-A1 METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — US disclosed
US-20120157696-A1 METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — US disclosed
US-20120157696-A1 METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — US disclosed
WO-2012082837-A1 METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — WO disclosed
WO-2012082837-A1 METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140364618-A1 Method of Making Indeno-Fused Naphthol Materials IDH3A, NQO1, IDH3B MEN1 595/4885KMT2A 1373/4885GAA 3190/4885
US-20120157696-A1 METHOD OF MAKING INDENO-FUSED NAPHTHOL MATERIALS NQO1, IDH3A, IDH2 MEN1 903/4885KMT2A 1788/4885GAA 2062/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.