Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.43 |
| ▸ | GRN | P28799 | 2/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9938273 | 0.87 | SMN1; SMN2 (0.46) | GRM5 | |
| SCHEMBL22383638 | 0.80 | GRN (0.52) | SRD5A2GRNSORT1 | |
| SCHEMBL9941529 | 0.78 | GRM5 (0.41) | GRM5SRD5A2GRNSORT1 | |
| SCHEMBL9941534 | 0.78 | GRM5 (0.41) | GRM5SRD5A2GRNSORT1 | |
| SCHEMBL9900971 | 0.75 | GRM5 (0.45) | GRM5CYP1A2 | |
| SCHEMBL6475045 | 0.74 | GRN (0.39) | GRNSORT1CYP1A2 | |
| SCHEMBL20477377 | 0.68 | SMN1; SMN2 (0.54) | CYP1A2 | |
| SCHEMBL6419868 | 0.68 | LMNA (0.51) | — | |
| SCHEMBL16404608 | 0.68 | KDM4E (0.50) | GRM5CYP1A2 | |
| SCHEMBL9900824 | 0.68 | GRM5 (0.42) | GRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651222-A1 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | Vanderbilt University (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012083224-A1 | BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2012-06-21 | — | — | WO | disclosed |