Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | GBA1 | P04062 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | PDE5A | O76074 | 1/20 | 0.77 |
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.74 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.74 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.74 |
| ▸ | KDM1A | O60341 | 2/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440311 | 0.87 | PDE5A (1.00) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL16404454 | 0.86 | KMT2A (0.76) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL16404494 | 0.82 | ABCG2 (0.95) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL1064726 | 0.82 | ABCG2 (1.00) | MEN1KMT2ALMNAMAPTPDE5A | |
| SCHEMBL16404472 | 0.81 | ABCG2 (0.87) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL1083764 | 0.81 | ABCG2 (1.00) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL16404331 | 0.79 | MEN1 (0.65) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL1063510 | 0.78 | ABCG2 (0.91) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL16404453 | 0.78 | MEN1 (0.73) | MEN1KMT2AKDM4ELMNAMAPT | |
| SCHEMBL14262975 | 0.77 | MEN1 (0.74) | MEN1KMT2AKDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | claimed |
| US-20140031547-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED | 2014-01-30 | — | — | US | claimed |
| EP-2651405-A2 | CASEIN KINASE 1 (CK1 ) INHIBITORS | Electrophoretics Limited (GB) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080729-A2 | CASEIN KINASE 1δ (CK1δ) INHIBITORS | ELECTROPHORETICS LIMITED (GB) | 2012-06-21 | — | — | WO | claimed |
| US-20240000821-A1 | CHEMICAL INHIBITORS AGAINST KINASES TO BLOCK TELOMERE ELONGATION IN CANCER | UNIV JOHNS HOPKINS (US) | 2024-01-04 | — | — | US | disclosed |
| US-20200078387-A1 | CHEMICAL INHIBITORS AGAINST KINASES TO BLOCK TELOMERE ELONGATION IN CANCER | THE JOHNS HOPKINS UNIVERSITY | 2020-03-12 | — | — | US | disclosed |
| WO-2018112342-A1 | CHEMICAL INHIBITORS AGAINST KINASES TO BLOCK TELOMERE ELONGATION IN CANCER | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-06-21 | — | — | WO | disclosed |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED (GB) | 2016-12-08 | — | — | US | disclosed |
| US-20140031547-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED | 2014-01-30 | — | — | US | disclosed |
| US-20140031547-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES | ELECTROPHORETICS LIMITED | 2014-01-30 | — | — | US | disclosed |
| EP-2651405-A2 | CASEIN KINASE 1 (CK1 ) INHIBITORS | Electrophoretics Limited (GB) | 2013-10-23 | — | — | EP | disclosed |
| WO-2012080729-A2 | CASEIN KINASE 1δ (CK1δ) INHIBITORS | ELECTROPHORETICS LIMITED (GB) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031547-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1G3 | MEN1 3661/4885KMT2A 1033/4885KDM4E 1436/4885 |
| US-20160354375-A1 | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS TAUOPATHIES | CSNK1G1, CSNK1A1, CSNK1D | MEN1 3510/4885KMT2A 810/4885KDM4E 1514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.