Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 8/20 | 0.49 |
| ▸ | TTK | P33981 | 8/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.49 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9937049 | 0.89 | PIM1 (0.52) | PIM1TTKPIM2HASPINKDM4E | |
| Hydrochloric Acid SCHEMBL9937475 | 0.88 | PIM1 (0.51) | PIM1TTKPIM2HASPINKDM4E | |
| SCHEMBL9937233 | 0.85 | PIM1 (0.48) | PIM1TTKPIM2HASPIN | |
| SCHEMBL11023707 | 0.83 | PIM1 (0.52) | PIM1TTKPIM2ALDH1A1POLB | |
| SCHEMBL9941041 | 0.81 | PIM1 (0.53) | PIM1TTKPIM2HASPINMEN1 | |
| SCHEMBL9937660 | 0.81 | PIM1 (0.60) | PIM1TTKPIM2 | |
| Hydrochloric Acid SCHEMBL9936599 | 0.80 | PIM1 (0.59) | PIM1TTKPIM2 | |
| SCHEMBL10218689 | 0.79 | PIM1 (0.45) | PIM1TTKPIM2 | |
| SCHEMBL18752168 | 0.77 | PIM1 (0.44) | PIM1TTKPIM2 | |
| SCHEMBL12466804 | 0.73 | PIM1 (0.74) | PIM1TTKPIM2HASPINKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614065-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012080990-A1 | SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-06-21 | — | — | WO | disclosed |