Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL85992 | 0.85 | NOS3 (0.42) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL11065611 | 0.85 | NOS3 (0.50) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL28406756 | 0.74 | NOS3 (0.63) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL13645494 | 0.73 | NOS3 (0.52) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL2075410 | 0.70 | NOS3 (1.00) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL6069929 | 0.70 | NOS3 (0.49) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL28228058 | 0.69 | NOS3 (0.47) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL8021974 | 0.69 | AKR1B1 (0.41) | NOS3NOS1NOS2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8324907 | 0.69 | NOS3 (0.96) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL27457493 | 0.68 | NOS3 (0.55) | NOS3NOS1NOS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651403-A2 | USE OF LP-PLA2 INHIBITORS IN THE TREATMENT AND PREVENTION OF EYE DISEASES | Glaxo Group Limited (GB) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080497-A2 | METHODS OF TREATMENT AND PREVENTION OF EYE DISEASES | GLAXO GROUP LIMITED (GB) | 2012-06-21 | — | — | WO | claimed |