SCHEMBL9938463

SCHEMBL9938463

O=CNc1cc(CC(O)NCCCCCCOCC(F)(F)c2ccccc2)ccc1O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 18/20 0.46
ADRB1 P08588 11/20 0.46
ADRB3 P13945 8/20 0.40
DRD2 P14416 3/20 0.35
SLC6A4 P31645 2/20 0.35
ADRA1A P35348 2/20 0.35
SLC6A3 Q01959 2/20 0.35
DRD3 P35462 2/20 0.35
PGR P06401 1/20 0.35
PTGS2 P35354 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
CYP2C19 P33261 1/20 0.35
KDM5A P29375 1/20 0.34
KDM4E B2RXH2 1/20 0.33
HTR1A P08908 1/20 0.33
CHRM5 P08912 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2516327 0.83 ADRB2 (0.45) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL185697 0.81 ADRB2 (0.58) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL9938462 0.81 ADRB2 (0.58) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL17185976 0.75 ADRB2 (0.46) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL9942423 0.75 ADRB2 (0.46) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL9942356 0.74 ADRB2 (0.43) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL9942398 0.74 ADRB2 (0.36) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL2131341 0.74 ADRB2 (0.36) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL2131348 0.74 ADRB2 (0.36) ADRB2ADRB1ADRB3DRD2SLC6A4
SCHEMBL9942349 0.73 ADRB2 (0.38) ADRB2ADRB1ADRB3DRD2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2736886-A1 SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS Boehringer Ingelheim International GmbH (DE) 2014-06-04 EP disclosed
EP-2651932-A1 BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS Boehringer Ingelheim International GmbH (DE) 2013-10-23 EP disclosed
EP-2651891-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS Boehringer Ingelheim International GmbH (DE) 2013-10-23 EP disclosed
WO-2013014060-A1 SUBSTITUTED QUINOLINES AND THEIR USE AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-01-31 WO disclosed
WO-2012080456-A1 BICYCLIC RING SYSTEM SUBSTITUTED AMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-21 WO disclosed
WO-2012080457-A1 BICYCLIC RING SYSTEM SUBSTITUTED SULFONAMIDE FUNCTIONALISED PHENOLS AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-06-21 WO disclosed