Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133568 | 1.00 | ELANE (0.53) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| SCHEMBL285949 | 1.00 | ELANE (0.53) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| SCHEMBL28176721 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| SCHEMBL28281300 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| SCHEMBL28299146 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10445713 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL9613925 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL2037585 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19834657 | 0.98 | ELANE (0.51) | ELANEATML3MBTL1SLC1A3ALDH1A1 | |
| Malonic Acid SCHEMBL9222807 | 0.91 | ELANE (0.46) | ELANEATML3MBTL1SLC1A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849034-A | EGFR inhibitors and methods of use thereof | 达纳－法伯癌症研究所公司 | 2018-03-27 | — | — | CN | disclosed |
| WO-2014154871-A1 | DYEING PROCESS USING AN IRIDOID COMPOUND AND DEVICES FOR THE SAME | L'OREAL (FR) | 2014-10-02 | — | — | WO | disclosed |
| CN-103804206-A | Synthetic process of dapoxetine hydrochloride | XU SHIMING | 2014-05-21 | — | — | CN | disclosed |
| CN-102229538-B | Method for synthesizing dapoxetine | UNIV CENTRAL SOUTH | 2013-11-13 | — | — | CN | disclosed |
| EP-2651902-A2 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | Reata Pharmaceuticals, Inc. (US) | 2013-10-23 | — | — | EP | disclosed |
| WO-2013045703-A1 | DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICE THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045704-A2 | DYE COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICES THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045702-A2 | DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A SPECIFIC NUCLEOPHILE OR AN AMINO OR THIO POLYMER, DYEING PROCESS, AND DEVICE THEREFOR | L'OREAL (FR) | 2013-04-04 | — | — | WO | disclosed |
| CN-101186612-B | Pyrroline derivative capable of inhibiting cell to release tumor necrotic factor and its preparation and application | TIANJIN HEMEI BIOLOG TECHNOLOGY CO LTD | 2012-10-03 | — | — | CN | disclosed |
| WO-2012083306-A2 | PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | WO | disclosed |
| CN-102229538-A | Method for synthesizing dapoxetine | UNIV CENTRAL SOUTH | 2011-11-02 | — | — | CN | disclosed |
| CN-101186612-A | Pyrroline derivative capable of inhibiting cell to release tumor necrotic factor and its preparation and application | TIANJIN HEMEI BIOLOG TECHNOLOG (CN) | 2008-05-28 | — | — | CN | disclosed |
| CN-1328277-C | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2007-07-25 | — | — | CN | disclosed |
| CN-1284945-A | Substituted pyriding and pyridazine compounds and their pharmaceutical use | AMGEN INC (US) | 2001-02-21 | — | — | CN | disclosed |
| CN-1246858-A | Substituted pyrimidine compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |
| CN-1246857-A | Substituted pyrimidinone and pyridinone compounds and their use | AMGEN INC (US) | 2000-03-08 | — | — | CN | disclosed |