SCHEMBL9939720

SCHEMBL9939720

O=C(O)c1ccc(-c2ccc3cc(CO)ccc3c2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 8/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
RARA P10276 2/20 0.51
RARG P13631 2/20 0.51
TSHR P16473 1/20 0.51
PTGES O14684 2/20 0.50
ALOX5 P09917 2/20 0.50
BCL2 P10415 1/20 0.49
RXRA P19793 2/20 0.49
RXRB P28702 2/20 0.49
ERN1 O75460 1/20 0.47
NPC1 O15118 1/20 0.47
HPGD P15428 1/20 0.47
RAB9A P51151 1/20 0.47
FOLH1 Q04609 1/20 0.46
MEN1 O00255 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
MTOR P42345 1/20 0.45
KMT2A Q03164 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31428506 0.85 GRIN2D (0.57) SMN1; SMN2TSHRNPC1HPGDRAB9A
SCHEMBL6551318 0.85 GRIN2D (0.57) SMN1; SMN2TSHRNPC1HPGDRAB9A
SCHEMBL3641834 0.83 RARB (0.58) RARBRARATSHRBCL2RXRA
SCHEMBL2362674 0.82 PTGES (0.56) RARBRARAPTGESALOX5BCL2
SCHEMBL2357478 0.82 PLAU (0.55) RARBRARARARGPTGESALOX5
SCHEMBL5047765 0.81 RARB (0.60) RARBSMN1; SMN2RARARARGTSHR
SCHEMBL9939192 0.81 EGFR (0.51) SMN1; SMN2ERN1HPGDMAPT
SCHEMBL4140814 0.81 BCL2 (0.73) SMN1; SMN2TSHRBCL2RXRARXRB
SCHEMBL29784246 0.81 BCL2 (0.73) SMN1; SMN2TSHRBCL2RXRARXRB
SCHEMBL21585549 0.80 GRIN2D (0.51) SMN1; SMN2TSHRNPC1HPGDRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2651871-A1 NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS N30 Pharmaceuticals, Inc. (US) 2013-10-23 EP claimed
WO-2012083171-A1 NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS N30 PHARMACEUTICALS, LLC (US) 2012-06-21 WO claimed
EP-2651871-A1 NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS N30 Pharmaceuticals, Inc. (US) 2013-10-23 EP disclosed
WO-2012083171-A1 NOVEL SUBSTITUTED BICYCLIC AROMATIC COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS N30 PHARMACEUTICALS, LLC (US) 2012-06-21 WO disclosed