Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 5/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9940783 | 0.88 | CYP3A4 (0.66) | CYP3A4CYP2D6 | |
| SCHEMBL9940593 | 0.87 | CYP3A4 (0.60) | CYP3A4 | |
| SCHEMBL9940724 | 0.87 | CYP3A4 (0.60) | CYP3A4CYP2D6 | |
| SCHEMBL9940728 | 0.87 | CYP3A4 (0.60) | CYP3A4 | |
| SCHEMBL15302767 | 0.86 | CYP3A4 (0.66) | CYP3A4CYP2D6 | |
| SCHEMBL15303069 | 0.86 | CYP3A4 (0.61) | CYP3A4MAOAMAOBPRKDCPIK3CA | |
| SCHEMBL18053791 | 0.83 | CYP3A4 (0.67) | CYP3A4CYP2D6 | |
| SCHEMBL15303128 | 0.82 | CYP3A4 (0.60) | CYP3A4CYP2D6 | |
| SCHEMBL15302856 | 0.82 | CYP3A4 (0.65) | CYP3A4CYP2D6 | |
| SCHEMBL18053772 | 0.81 | CYP3A4 (0.67) | CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9944638-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND US (IE) | 2018-04-17 | — | — | US | disclosed |
| US-9944638-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND US (IE) | 2018-04-17 | — | — | US | disclosed |
| US-9944638-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND US (IE) | 2018-04-17 | — | — | US | disclosed |
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-08-18 | — | — | US | disclosed |
| US-9321768-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| US-9321768-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| US-9321768-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN SCIENCES IRELAND UC (IE) | 2016-04-26 | — | — | US | disclosed |
| EP-2651922-B1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-02-24 | — | — | EP | disclosed |
| US-20150073013-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN SCIENCES IRELAND UC (IE) | 2015-03-12 | — | — | US | disclosed |
| US-8921560-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2014-12-30 | — | — | US | disclosed |
| US-8921560-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2014-12-30 | — | — | US | disclosed |
| US-8921560-B2 | Indoles as respiratory syncytial virus antiviral agents | JANSSEN R&D IRELAND (IE) | 2014-12-30 | — | — | US | disclosed |
| EP-2651922-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | Janssen R&D Ireland (IE) | 2013-10-23 | — | — | EP | disclosed |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2013-10-10 | — | — | US | disclosed |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2013-10-10 | — | — | US | disclosed |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2013-10-10 | — | — | US | disclosed |
| WO-2012080447-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |
| WO-2012080447-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | JANSSEN R&D IRELAND (IE) | 2012-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237083-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | IDO1, IDO2, INMT | CYP3A4 81/4885MAOA 15/4885MAOB 14/4885 |
| US-20150073013-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | IDO1, IDO2, INMT | CYP3A4 81/4885MAOA 15/4885MAOB 14/4885 |
| US-20130267555-A1 | INDOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS | IDO1, IDO2, INMT | CYP3A4 81/4885MAOA 15/4885MAOB 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.