Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.51 |
| ▸ | TTK | P33981 | 11/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9941053 | 0.95 | MAPKAPK5 (0.50) | MAPKAPK5TTKFLT3ADORA3 | |
| SCHEMBL9941237 | 0.92 | TTK (0.49) | MAPKAPK5TTKADORA3 | |
| SCHEMBL9941201 | 0.84 | TTK (0.54) | MAPKAPK5TTK | |
| SCHEMBL9938292 | 0.83 | TTK (0.55) | MAPKAPK5TTK | |
| SCHEMBL9941127 | 0.83 | TTK (0.53) | MAPKAPK5TTK | |
| SCHEMBL9940914 | 0.82 | TTK (0.51) | MAPKAPK5TTK | |
| SCHEMBL9940873 | 0.82 | TTK (0.51) | MAPKAPK5TTK | |
| SCHEMBL9941138 | 0.82 | TTK (0.57) | MAPKAPK5TTKFLT3ADORA3 | |
| SCHEMBL9940987 | 0.81 | TTK (0.49) | MAPKAPK5TTK | |
| SCHEMBL9941295 | 0.81 | TTK (0.46) | MAPKAPK5TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2651948-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | Bayer Intellectual Property GmbH (DE) | 2013-10-23 | — | — | EP | claimed |
| WO-2012080229-A1 | IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-06-21 | — | — | WO | claimed |